┌─────────────────────────────────────────────────────────┐ │ PHARMACOLOGY YOU SEE FRAMEWORK │ ├────────────────────────────┬────────────────────────────┤ │ PHARMACOKINETICS │ PHARMACODYNAMICS │ │ What the body does to │ What the drug does to │ │ the drug (ADME)│ the body │ └─────────────┬──────────────┴──────────────┬─────────────┘ ▼ ▼ ┌────────────────────────────┐┌───────────────────────────┐ │ ORGAN SYSTEM PATHS ││ CLINICAL THERAPEUTICS │ │ • Autonomic Nervous System ││ • Antimicrobial Actions │ │ • Cardiovascular & Renal ││ • Cancer Chemotherapies │ │ • Central Nervous System ││ • Endocrine Interventions │ └────────────────────────────┘└───────────────────────────┘ 1. General Principles
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Modern pharmacology faces several formidable challenges. First, threatens to return society to a pre-antibiotic era. The overuse and misuse of antibiotics have selected for resistant bacteria, such as MRSA and carbapenem-resistant Enterobacteriaceae. Pharmacologists are now exploring novel approaches, including antimicrobial peptides, bacteriophage therapy, and adjuvants that resensitize bacteria to existing drugs. The overuse and misuse of antibiotics have selected
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